Compounds > 2-[(6-chloro-3-pyridinyl)sulfonylamino]-N-[(4-methylphenyl)methyl]benzamide

Page last updated: 2024-08-03 10:11:16

2-[(6-chloro-3-pyridinyl)sulfonylamino]-N-[(4-methylphenyl)methyl]benzamide

Description

2-[(6-chloro-3-pyridinyl)sulfonylamino]-N-[(4-methylphenyl)methyl]benzamide : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	24686397
CHEMBL ID	1580621
CHEBI ID	105565

Synonyms (14)

Synonym
REGID_FOR_CID_24686397
MLS001151251
smr000688138
CHEBI:105565
AKOS001455875
HMS2966K16
CHEMBL1580621
2-[(6-chloro-3-pyridinyl)sulfonylamino]-n-[(4-methylphenyl)methyl]benzamide
Q27183314
Z45579520
2-(6-chloropyridine-3-sulfonamido)-n-[(4-methylphenyl)methyl]benzamide
1016469-56-9
EN300-26593529
2-[(6-chloropyridin-3-yl)sulfonylamino]-n-[(4-methylphenyl)methyl]benzamide

Drug Classes (1)

Class	Description
benzamides

Protein Targets (14)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
TSHR protein	Homo sapiens (human)	Potency	119.9550	AID602292
Smad3	Homo sapiens (human)	Potency	15.8489	AID588855
PINK1	Homo sapiens (human)	Potency	44.6684	AID624263
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	12.5893	AID2326
Parkin	Homo sapiens (human)	Potency	44.6684	AID624263
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	63.0957	AID504332
chromobox protein homolog 1	Homo sapiens (human)	Potency	89.1251	AID540317
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	20.5962	AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	44.6684	AID743266
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	13.5346	AID2546; AID2551
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	0.7079	AID504327
Alpha-synuclein	Homo sapiens (human)	Potency	35.4813	AID652106
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	11.2202	AID652104

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
high affinity choline transporter 1 isoform a	Homo sapiens (human)	IC50	5.7688	AID504840; AID588401

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	1 (20.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%

Substance	Classes	Roles	Relationship Strength
3-aminobenzamide	benzamides; substituted aniline	EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor	low
dan 2163	aromatic amide; aromatic amine; benzamides; pyrrolidines; sulfone	environmental contaminant; second generation antipsychotic; xenobiotic	low
benzamide	benzamides		low
bromopride	benzamides		low
ci 994	acetamides; benzamides; substituted aniline	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	low
cisapride	benzamides		low
2-hexyloxybenzamide	aromatic ether; benzamides	antifungal agent	low
itopride	benzamides		low
labetalol	benzamides; benzenes; phenols; primary carboxamide; salicylamides; secondary alcohol; secondary amino compound		low
lorglumide	benzamides; dicarboxylic acid monoamide; dichlorobenzene; glutamic acid derivative		low
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamide	benzamides; hydroxamic acid; secondary carboxamide; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	low
metoclopramide	benzamides; monochlorobenzenes; substituted aniline; tertiary amino compound	antiemetic; dopaminergic antagonist; environmental contaminant; gastrointestinal drug; xenobiotic	low
moclobemide	benzamides; monochlorobenzenes; morpholines	antidepressant; environmental contaminant; xenobiotic	low
entinostat	benzamides; carbamate ester; primary amino compound; pyridines; substituted aniline	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	low
deet	benzamides; monocarboxylic acid amide	environmental contaminant; insect repellent; xenobiotic	low
acecainide	acetamides; benzamides	anti-arrhythmia drug	low
nemonapride	benzamides; monochlorobenzenes; monomethoxybenzene; N-alkylpyrrolidine; secondary amino compound; secondary carboxamide; substituted aniline		low
niclosamide	benzamides; C-nitro compound; monochlorobenzenes; salicylanilides; secondary carboxamide	anthelminthic drug; anticoronaviral agent; antiparasitic agent; apoptosis inducer; molluscicide; piscicide; STAT3 inhibitor	low
picotamide	benzamides		low
procainamide	benzamides	anti-arrhythmia drug; platelet aggregation inhibitor; sodium channel blocker	low
procarbazine	benzamides; hydrazines	antineoplastic agent	low
proglumetacin	aromatic ether; benzamides; carboxylic ester; monochlorobenzenes; N-acylindole; N-alkylpiperazine	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; lipoxygenase inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug; prodrug	low
proglumide	benzamides; dicarboxylic acid monoamide; glutamine derivative; racemate	anti-ulcer drug; cholecystokinin antagonist; cholinergic antagonist; delta-opioid receptor agonist; drug metabolite; gastrointestinal drug; opioid analgesic; xenobiotic metabolite	low
imatinib	aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines	antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor	low
sulpiride	benzamides; N-alkylpyrrolidine; sulfonamide	antidepressant; antiemetic; antipsychotic agent; dopaminergic antagonist	low
tiapride	benzamides		low
trimethobenzamide	benzamides; tertiary amino compound	antiemetic	low
troxipide	benzamides		low
zm 336372	benzamides		low
iodohippuric acid	benzamides; N-acylglycine; organoiodine compound		low
benzoylarginine-2-naphthylamide	arginine derivative; benzamides; N-(2-naphthyl)carboxamide		low
4-(benzoylamino)-2-hydroxybenzoic acid	benzamides		low
ameltolide	benzamides		low
antimycin a	benzamides; formamides; macrodiolide; phenols	antifungal agent; mitochondrial respiratory-chain inhibitor; piscicide	low
rebemide	benzamides		low
2,6-dichlorobenzamide	benzamides; dichlorobenzene	herbicide; marine xenobiotic metabolite	low
fluorophene	benzamides		low
2-toluanilide	benzamides; benzanilide fungicide		low
2-bromo-N-phenylbenzamide	benzamides		low
xipamide	benzamides		low
capobenic acid	benzamides		low
pronamide	benzamides; dichlorobenzene; terminal acetylenic compound	agrochemical; herbicide	low
clanobutin	benzamides		low
nitazoxanide	benzamides; carboxylic ester		low
Flamprop	benzamides		low
N-[4-(dimethylamino)phenyl]-3,4,5-trimethoxybenzamide	benzamides		low
endralazine	benzamides		low
flutolanil	(trifluoromethyl)benzenes; aromatic ether; benzamides; benzanilide fungicide	antifungal agrochemical; EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor	low
encainide	benzamides; piperidines	anti-arrhythmia drug; sodium channel blocker	low
nelfinavir	aryl sulfide; benzamides; organic heterobicyclic compound; phenols; secondary alcohol; tertiary amino compound	antineoplastic agent; HIV protease inhibitor	low
n-benzoylpiperidine	benzamides; N-acylpiperidine		low
pancopride	benzamides		low
octylonium	benzamides		low
parsalmide	benzamides		low
isoxaben	benzamides; isoxazoles	cellulose synthesis inhibitor; herbicide	low
4-aminobenzamide	benzamides		low
4-Methoxybenzamide	benzamides		low
benzoyltyrosine ethyl ester	benzamides; ethyl ester; L-tyrosine derivative; phenols	chromogenic compound	low
salifungin	benzamides		low
n-benzoyl-l-arginine	benzamides; N-acyl-L-arginine		low
gr 127935	1,2,4-oxadiazole; benzamides; N-alkylpiperazine; N-arylpiperazine		low
zacopride	benzamides		low
mozavaptan	benzamides	aquaretic	low
mosapride	aromatic ether; benzamides; monochlorobenzenes; monofluorobenzenes; morpholines; secondary carboxamide; substituted aniline; tertiary amino compound		low
zoxamide	alpha-chloroketone; benzamides; dichlorobenzene		low
procainamide 4-hydroxylamine	benzamides; hydroxylamines	drug metabolite	low
ly 188544	benzamides		low
gr 55562	benzamides		low
n-(2,6-dimethylphenyl)-4-(((diethylamino)acetyl)amino)benzamide	benzamides		low
tariquidar	benzamides		low
n-benzoyltyrosine	benzamides; N-acyl-L-tyrosine		low
rp 73401	aromatic ether; benzamides; chloropyridine; monocarboxylic acid amide	anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; phosphodiesterase IV inhibitor	low
brovanexine	benzamides		low
aminopotentidine	aromatic ether; benzamides; guanidines; nitrile; piperidines; substituted aniline	H2-receptor antagonist	low
asperphenamate	benzamides; carboxylic ester; L-phenylalanine derivative	antineoplastic agent	low
N-(3-fluorophenyl)benzamide	benzamides		low
benzoylphenylalanine	benzamides; N-acyl-amino acid		low
2-methoxy-N-[2-(methylthio)phenyl]benzamide	benzamides		low
2-(4-fluorobenzoylamino)benzoic acid methyl ester	benzamides		low
xv 638	1,3-thiazoles; benzamides; diazepanone; diol; secondary alcohol; secondary carboxamide; ureas	HIV protease inhibitor	low
roflumilast	aromatic ether; benzamides; chloropyridine; cyclopropanes; organofluorine compound	anti-asthmatic drug; phosphodiesterase IV inhibitor	low
2-(3-benzamidophenoxy)acetic acid	benzamides		low
ck-0944666	benzamides; indoles; organofluorine compound	actin polymerisation inhibitor	low
gw9662	benzamides		low
N-[2-(1-cyclohexenyl)ethyl]-4-(4-morpholinylmethyl)benzamide	benzamides		low
2-methoxy-N-[6-(1-oxobutylamino)-3-pyridinyl]benzamide	benzamides		low
N-[4-chloro-2-[(2,4-dimethoxyanilino)-oxomethyl]phenyl]-2-furancarboxamide	benzamides		low
[3-[3-(5-methyl-2-furanyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-phenylmethanone	benzamides; N-acylpiperidine		low
4-methyl-N-[2-[4-(2-methyl-1-oxopropyl)-1-piperazinyl]phenyl]benzamide	benzamides		low
N-[2-(2-ethyl-5-tetrazolyl)phenyl]-3-(1-tetrazolyl)benzamide	benzamides		low
N-[2-(2-ethyl-5-tetrazolyl)phenyl]-4-(1-tetrazolyl)benzamide	benzamides		low
N-[2,5-diethoxy-4-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]phenyl]-2-furancarboxamide	benzamides		low
(2,4-difluorophenyl)-[3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone	benzamides; N-acylpiperidine		low
2-ethoxy-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide	benzamides		low
4-methyl-N-(2-methyl-5-tetrazolyl)benzamide	benzamides		low
N-[2,5-dimethoxy-4-[[2-(4-morpholinyl)-1-oxoethyl]amino]phenyl]benzamide	benzamides		low
N-(4-fluorophenyl)-4-(2-oxolanylmethylsulfamoyl)benzamide	benzamides		low
azidopine	benzamides		low
4-methoxy-N1,N3-bis(3-pyridinyl)benzene-1,3-dicarboxamide	benzamides		low
2,3,4,5,6-pentafluoro-N-(phenylmethyl)benzamide	benzamides		low
N-(1,1-dioxo-3-thiolanyl)-N-(thiophen-2-ylmethyl)benzamide	benzamides		low
N-(3-methoxyphenyl)-2-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]benzamide	benzamides		low
2-[[(4-acetyloxy-3-methoxyphenyl)-oxomethyl]amino]-5-hydroxybenzoic acid	benzamides		low
N-(3-acetamidophenyl)-4-methoxybenzamide	benzamides		low
N-(3-acetamidophenyl)-3-chlorobenzamide	benzamides		low
4-methoxy-N-(5-methyl-3-isoxazolyl)benzamide	benzamides		low
4-tert-butyl-N-[4-(4-morpholinyl)phenyl]benzamide	benzamides		low
N-(2-fluorophenyl)-4-phenylmethoxybenzamide	benzamides		low
4-methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide	benzamides		low
4-methyl-N-[4-(4-morpholinyl)phenyl]benzamide	benzamides		low
4-methoxy-N-(3-pyridinylmethyl)benzamide	benzamides		low
2-methoxy-N-(2-pyridinyl)benzamide	benzamides		low
N-[3-(4-oxo-3,1-benzoxazin-2-yl)phenyl]benzamide	benzamides		low
N-[(4-pyrimidinylthio)methyl]benzamide	benzamides		low
N-(5-ethyl-1,3,4-thiadiazol-2-yl)-3-methoxybenzamide	benzamides		low
N-(4-acetamidophenyl)-2-bromobenzamide	benzamides		low
N-(5-acetyl-4-methyl-2-thiazolyl)-4-tert-butylbenzamide	benzamides		low
N-(5-acetyl-4-methyl-2-thiazolyl)-2-methylbenzamide	benzamides		low
2-ethoxy-N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]benzamide	benzamides		low
N-(3,4-dimethoxyphenyl)-4-methoxybenzamide	benzamides		low
N-[2-[(4-methylanilino)-oxomethyl]phenyl]-3-pyridinecarboxamide	benzamides		low
N-[4-(2,5-dimethyl-1-pyrrolyl)phenyl]benzamide	benzamides		low
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-methoxybenzamide	benzamides		low
N-[4-(2-methyl-4-thiazolyl)phenyl]benzamide	benzamides		low
N-(3-acetamidophenyl)-2-chlorobenzamide	benzamides		low
3-ethoxy-N-(2-thiazolyl)benzamide	benzamides		low
2-bromo-N-(3-methoxyphenyl)benzamide	benzamides		low
N-(2,4-difluorophenyl)-3-methoxybenzamide	benzamides		low
4-[[(4-acetyloxy-3-methoxyphenyl)-oxomethyl]amino]benzoic acid	benzamides		low
acetic acid [4-[(4-hydroxyanilino)-oxomethyl]-2-methoxyphenyl] ester	benzamides		low
N-(4-benzamido-2-chlorophenyl)-2-furancarboxamide	benzamides		low
2-(hydroxymethyl)-N-(phenylmethyl)benzamide	benzamides		low
2-[[(3-methylphenyl)-oxomethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid	benzamides		low
2-chloro-4-methyl-N-[4-(4-methyl-1-piperazinyl)phenyl]benzamide	benzamides		low
2-ethoxy-N-(2-hydroxyphenyl)benzamide	benzamides		low
3-[[(3-chloro-4-ethoxyphenyl)-oxomethyl]amino]benzoic acid	benzamides		low
2-methoxy-N-(4-methylphenyl)-4-(methylthio)benzamide	benzamides		low
3-[[(4-methoxyphenyl)-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester	benzamides		low
2-methoxy-3-methyl-N-[4-(4-morpholinylmethyl)phenyl]benzamide	benzamides		low
N-(4-anilinophenyl)-3,4-dimethoxybenzamide	benzamides		low
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-4-methylbenzamide	benzamides		low
N-[[(6-methyl-4-pyrimidinyl)thio]methyl]benzamide	benzamides		low
N-(3-acetamidophenyl)-2-methoxybenzamide	benzamides		low
2-bromo-N-[3-(1-oxopropylamino)phenyl]benzamide	benzamides		low
N-(3-acetylphenyl)-3-ethoxybenzamide	benzamides		low
2-[[(3-bromophenyl)-oxomethyl]amino]-5-hydroxybenzoic acid	benzamides		low
1-azepanyl-[4-[(phenylthio)methyl]phenyl]methanone	benzamides		low
4-chloro-N-[4-(2-imidazo[1,2-a]pyridinyl)phenyl]benzamide	benzamides		low
3,4,5-triethoxy-N-(1H-1,2,4-triazol-5-yl)benzamide	benzamides		low
3-[[[3-(4-methoxyphenyl)phenyl]-oxomethyl]amino]benzoic acid	benzamides		low
3-[(4-ethoxyphenoxy)methyl]-N,N-diethylbenzamide	benzamides		low
2-[[anilino(oxo)methyl]amino]-N-(phenylmethyl)benzamide	benzamides		low
4-tert-butyl-N-(4-methyl-3-nitrophenyl)benzamide	benzamides		low
N-(3-methoxyphenyl)-4-[(2-methyl-1-oxopropyl)amino]benzamide	benzamides		low
N-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-3,4,5-trimethoxybenzamide	benzamides		low
4-chloro-3-[[(2-methyl-3-nitrophenyl)-oxomethyl]amino]benzoic acid methyl ester	benzamides		low
N-[3-chloro-4-(1-pyrrolidinyl)phenyl]-2-nitrobenzamide	benzamides		low
N-(4-methoxyphenyl)-2-(methylthio)benzamide	benzamides		low
N-[3-[[(3,5-dimethoxyphenyl)-oxomethyl]amino]phenyl]carbamic acid ethyl ester	benzamides		low
2,4-dimethyl-N-[4-(1-pyrrolidinyl)phenyl]benzamide	benzamides		low
N-(7-bromo-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)-3-methoxybenzamide	benzamides		low
5-chloro-N-(2-furanylmethyl)-2-[[(4-methoxyphenyl)-oxomethyl]amino]benzamide	benzamides		low
4-[(2-bromophenoxy)methyl]-N-[4-[(3,5-dimethyl-1-pyrazolyl)methyl]phenyl]benzamide	benzamides		low
3-bromo-5-ethoxy-N-(4-fluorophenyl)-4-methoxybenzamide	benzamides		low
2-chloro-N-[3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-5-(1,2,4-triazol-4-yl)benzamide	benzamides		low
3-[[(3,5-dichloro-4-ethoxyphenyl)-oxomethyl]amino]benzoic acid	benzamides		low
4-[4-[[(3,4-dimethylphenyl)-oxomethyl]amino]phenoxy]phthalic acid	benzamides		low
5-ethyl-2-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]-3-thiophenecarboxylic acid ethyl ester	benzamides		low
2-bromo-N-[3-(1-oxobutylamino)phenyl]benzamide	benzamides		low
3-chloro-N-[3-nitro-5-(2-pyridinylthio)phenyl]benzamide	benzamides		low
N-[4-chloro-2-[(2-ethoxyanilino)-oxomethyl]phenyl]-2-furancarboxamide	benzamides		low
4-[[[3-(4-morpholinylsulfonyl)phenyl]-oxomethyl]amino]benzoic acid ethyl ester	benzamides		low
3,4-dimethoxy-N-[4-[oxo(1-piperidinyl)methyl]phenyl]benzamide	benzamides		low
2-fluoro-N-[4-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]phenyl]benzamide	benzamides		low
N-(4-benzamido-3-methylphenyl)-1,3-benzodioxole-5-carboxamide	benzamides		low
N-(3-benzamidophenyl)-1,3-benzodioxole-5-carboxamide	benzamides		low
N-[2,2-dichloro-1-(4-chlorophenyl)sulfonylethenyl]benzamide	benzamides		low
2-[[[3-[2-(4-methylphenyl)sulfonylethylthio]phenyl]-oxomethyl]amino]benzoic acid	benzamides		low
4-chloro-N-[3-chloro-4-(4-morpholinyl)phenyl]benzamide	benzamides		low
N-(3-methoxyphenyl)-4-(1-oxopropylamino)benzamide	benzamides		low
N-[5-(4-tert-butylphenyl)-1,3,4-thiadiazol-2-yl]-4-methylbenzamide	benzamides		low
[2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone	benzamides; N-acylpiperidine		low
N-[2,5-diethoxy-4-[[(3-methoxyanilino)-sulfanylidenemethyl]amino]phenyl]-4-methylbenzamide	benzamides		low
N-[4-[[anilino(sulfanylidene)methyl]amino]-2,5-diethoxyphenyl]-4-methoxybenzamide	benzamides		low
N-[4-[[anilino(sulfanylidene)methyl]amino]-2,5-diethoxyphenyl]benzamide	benzamides		low
2-(4-chloro-3-methylphenoxy)acetic acid [4-[(4-methylanilino)-oxomethyl]phenyl] ester	benzamides		low
2-(3-chlorophenoxy)acetic acid [4-[(4-methylanilino)-oxomethyl]phenyl] ester	benzamides		low
2-(4-chloro-2-methylphenoxy)acetic acid [4-[(4-methylanilino)-oxomethyl]phenyl] ester	benzamides		low
3-(1,3-dioxo-2-isoindolyl)propanoic acid [4-[(4-methylanilino)-oxomethyl]phenyl] ester	benzamides		low
5-bromo-2-furancarboxylic acid (3-benzamidophenyl) ester	benzamides		low
(4-ethoxyphenyl)-[4-[(4-ethoxyphenyl)-oxomethyl]-1,4-diazepan-1-yl]methanone	benzamides		low
[4-[(2-bromophenoxy)methyl]phenyl]-(1-piperidinyl)methanone	benzamides; N-acylpiperidine		low
3-[(4-bromophenoxy)methyl]-N-(5-methyl-3-isoxazolyl)benzamide	benzamides		low
3-methyl-N-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]benzamide	benzamides		low
N-[4-[methyl(phenyl)sulfamoyl]phenyl]benzamide	benzamides		low
N-[4-[(N-methylanilino)-oxomethyl]phenyl]-2-furancarboxamide	benzamides		low
3-[[[3-(1-azepanylsulfonyl)-4-chlorophenyl]-oxomethyl]amino]benzoic acid	benzamides		low
2-[2-nitro-4-(trifluoromethyl)phenoxy]-N-phenylbenzamide	benzamides		low
4-chloro-N-[2-(4-methylsulfonyl-1-piperazinyl)phenyl]benzamide	benzamides		low
2-[[[(4-methoxyphenyl)-oxomethyl]amino]methyl]-5-phenyl-3-furancarboxylic acid	benzamides		low
N-(3,5-dichlorophenyl)-2-(methanesulfonamido)benzamide	benzamides		low
N-(5-chloro-2-methylphenyl)-4-[(4-chloro-1-pyrazolyl)methyl]benzamide	benzamides		low
2-[[2-[(4-chlorophenyl)thio]-1-oxoethyl]amino]-N-(4-methoxyphenyl)benzamide	benzamides		low
4-methoxy-N-[2-(4-morpholinyl)phenyl]-3-nitrobenzamide	benzamides		low
2-bromo-N-[4-(4-methyl-1-piperazinyl)phenyl]benzamide	benzamides		low
N-[4-[[[(5-bromo-2-furanyl)-oxomethyl]hydrazo]-oxomethyl]phenyl]benzamide	benzamides		low
5-bromo-2-methoxy-3-methyl-N-[4-(4-methylsulfonyl-1-piperazinyl)phenyl]benzamide	benzamides		low
4-methoxy-N-[4-[[(1-oxopropylamino)-sulfanylidenemethyl]amino]phenyl]benzamide	benzamides		low
2-[[(3,5-dimethoxyphenyl)-oxomethyl]amino]-4,5-dimethoxybenzoic acid methyl ester	benzamides		low
2,4,5-trimethoxy-N-(2-phenylphenyl)benzamide	benzamides		low
3-ethoxy-N-[3-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide	benzamides		low
2-[[[3-methyl-4-[[2-(3-nitrophenoxy)-1-oxoethyl]amino]phenyl]-oxomethyl]amino]benzoic acid	benzamides		low
4-methyl-N-[2-methyl-1,3-bis[(4-methyl-1,2,5-oxadiazol-3-yl)oxy]propan-2-yl]benzamide	benzamides		low
[4-[(2,4-dichlorophenoxy)methyl]phenyl]-(4-methyl-1-piperazinyl)methanone	benzamides		low
N-(2-furanylmethyl)-2-[[[2-[(4-methylphenyl)sulfonyl-(phenylmethyl)amino]phenyl]-oxomethyl]amino]benzamide	benzamides		low
2-[(2-cyanophenyl)thio]-N-[4-[dimethylamino(oxo)methyl]phenyl]benzamide	benzamides		low
N-(2-furanylmethyl)-2-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide	benzamides		low
N-[3-[[(4-nitrophenyl)-oxomethyl]amino]phenyl]-2-furancarboxamide	benzamides		low
N-[(3-benzamidoanilino)-sulfanylidenemethyl]-2-thiophenecarboxamide	benzamides		low
3-chloro-N-[4-[(1-oxo-2-phenylethyl)amino]phenyl]benzamide	benzamides		low
N-(3,4-dimethoxyphenyl)-4-[(4-phenyl-1-piperazinyl)methyl]benzamide	benzamides		low
4-cyano-N-methyl-N-[5-(2-pyridinyl)-1,3,4-thiadiazol-2-yl]benzamide	benzamides		low
4-tert-butyl-N-[2,5-dimethoxy-4-[[1-oxo-2-(1-piperidinyl)ethyl]amino]phenyl]benzamide	benzamides		low
(2,6-difluorophenyl)-[4-(5-fluoro-2-methyl-1-benzimidazolyl)-1-piperidinyl]methanone	benzamides; N-acylpiperidine		low
4-chloro-N-[3-cyano-4-(phenylthio)phenyl]benzamide	benzamides		low
(4-chlorophenyl)-[4-[[(2,4-dichlorophenyl)thio]methyl]-4-hydroxy-1-piperidinyl]methanone	benzamides; N-acylpiperidine		low
N-(4-bromo-2,6-dimethylphenyl)-2-methoxybenzamide	benzamides		low
4-[[(3,6-dichloro-2-methoxyphenyl)-oxomethyl]amino]benzoic acid propyl ester	benzamides		low
N-(2,4-dichlorophenyl)-4-phenylbenzamide	benzamides		low
4-butoxy-N-[4-[4-(2-methyl-1-oxopropyl)-1-piperazinyl]phenyl]benzamide	benzamides		low
fm19g11	benzamides		low
N-[4-[(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]phenyl]-2-nitrobenzamide	benzamides		low
3-[(2,5-dichlorophenoxy)methyl]-N-(2,6-dimethylphenyl)benzamide	benzamides		low
2-[[[(3-methyl-1-oxobutyl)amino]-sulfanylidenemethyl]amino]-N-phenylbenzamide	benzamides		low
acetic acid [4-[[3-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]anilino]-oxomethyl]phenyl] ester	benzamides		low
4-[[(4-tert-butylphenyl)-oxomethyl]amino]-3-methyl-2-sulfanylidene-5-thiazolecarboxylic acid ethyl ester	benzamides		low
3-methoxy-N-(2,3,4-trifluorophenyl)benzamide	benzamides		low
2-phenylacetic acid [2-[4-[(4-ethoxyanilino)-oxomethyl]anilino]-2-oxoethyl] ester	benzamides		low
4-[[(2-nitrophenyl)-oxomethyl]amino]benzoic acid propyl ester	benzamides		low
2-[[oxo-(2,3,4,5,6-pentafluorophenyl)methyl]amino]benzoic acid ethyl ester	benzamides		low
2-bromo-N-[3-(1-oxopentylamino)phenyl]benzamide	benzamides		low
4-[(2,4-dichlorophenoxy)methyl]-N-[2-(dimethylamino)ethyl]benzamide	benzamides		low
3-methoxy-N-[2-(3-methoxyphenoxy)ethyl]benzamide	benzamides		low
N-[4-(diethylsulfamoyl)phenyl]-4-(4-morpholinylmethyl)benzamide	benzamides		low
3,5-dimethyl-N-[4-[(1-oxo-2-phenylethyl)amino]phenyl]benzamide	benzamides		low
3-[[[3-[(3-nitrophenyl)sulfamoyl]phenyl]-oxomethyl]amino]benzoic acid	benzamides		low
2-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(3-methoxyphenyl)benzamide	benzamides		low
4-chloro-3-[(2,5-dimethylphenyl)sulfamoyl]-N-(2-phenylphenyl)benzamide	benzamides		low
4-methyl-N-(2-phenylphenyl)-3-(phenylsulfamoyl)benzamide	benzamides		low
2-[2-[[3-(1,3-benzoxazol-2-yl)anilino]-oxomethyl]phenyl]benzoic acid	benzamides		low
3,4-dimethoxy-N-[4-(2,2,3,3-tetrafluoropropoxy)-3-(trifluoromethyl)phenyl]benzamide	benzamides		low
1-azepanyl-[2-[4-(difluoromethylthio)anilino]phenyl]methanone	benzamides		low
3-[[(4-tert-butylphenyl)-oxomethyl]amino]-1H-1,2,4-triazole-5-carboxylic acid methyl ester	benzamides		low
2-bromo-N-(4-ethylphenyl)benzamide	benzamides		low
4-amino-N-(2-methoxyphenyl)benzamide	benzamides		low
4-(difluoromethoxy)-N-[5-[[4-(difluoromethylthio)phenyl]methyl]-2-thiazolyl]benzamide	benzamides		low
2-[(4-ethoxyphenyl)sulfonylamino]-N-[2-(4-morpholinyl)phenyl]benzamide	benzamides		low
4-(dimethylamino)-N-[2-(1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide	benzamides		low
2-[(2,5-dimethylphenyl)sulfonylamino]-N-[4-(2-pyrimidinylsulfamoyl)phenyl]benzamide	benzamides		low
2-[(5-chloro-2-thiophenyl)sulfonylamino]-N-(2-methoxy-5-methylphenyl)benzamide	benzamides		low
4-methoxy-N-[1-methyl-2-oxo-6-(trifluoromethyl)-3-pyridinyl]benzamide	benzamides		low
N-[4-bromo-3-(trifluoromethyl)phenyl]-2,4,6-trimethylbenzamide	benzamides		low
4-methyl-N-[1-methyl-2-oxo-6-(trifluoromethyl)-3-pyridinyl]benzamide	benzamides		low
4-[2-(4-fluoroanilino)-2-oxoethoxy]-3-methoxy-N-[4-(4-methoxyphenyl)-5-methyl-2-thiazolyl]benzamide	benzamides		low
3-[3-[2-(2-carbamoylphenoxy)-1-oxoethyl]-2,5-dimethyl-1-pyrrolyl]propanoic acid methyl ester	benzamides		low
4-methyl-N-[4-(2-methyl-4-thiazolyl)phenyl]benzamide	benzamides		low
5-(dimethylsulfamoyl)-N-(diphenylmethyl)-2-(1-pyrrolidinyl)benzamide	benzamides		low
2-[(3-fluoro-4-methoxyphenyl)methoxy]benzamide	benzamides		low
N-(4-chloro-2-methoxy-5-methylphenyl)-4-[(3,4-difluorophenyl)sulfonylamino]benzamide	benzamides		low
2-[[(3-methylphenyl)-oxomethyl]amino]benzoic acid (3,5-dimethyl-4-isoxazolyl)methyl ester	benzamides		low
4-(dimethylsulfamoyl)-N-(3-methylphenyl)benzamide	benzamides		low
N-[5-chloro-2-(4-methyl-1-piperazinyl)phenyl]-3-(dimethylsulfamoyl)benzamide	benzamides		low
3-methoxy-N-(4-methyl-2-thiazolyl)benzamide	benzamides		low
3-(diethylsulfamoyl)-N-(3,5-dimethylphenyl)benzamide	benzamides		low
3,4-dimethyl-N-[4-(4-methylpiperazino)benzyl]benzamide	benzamides		low
N-[4-(5-oxazolyl)phenyl]benzamide	benzamides		low
N1-(2,6-dimorpholino-3-pyridyl)-4-methylbenzamide	benzamides		low
2-chloro-N-[3-cyano-4-[(4-methoxyphenyl)thio]phenyl]benzamide	benzamides		low
N-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-3,4-dimethylbenzamide	benzamides		low
sirtinol	aldimine; benzamides; naphthols	anti-inflammatory agent; EC 3.5.1.98 (histone deacetylase) inhibitor; Sir2 inhibitor	low
N-[1-(3-methoxyphenyl)-3-(1-naphthalenylamino)-3-oxopropyl]benzamide	benzamides		low
N-[3-(1-naphthalenylamino)-3-oxo-1-phenylpropyl]benzamide	benzamides		low
4-chloro-3-(diethylsulfamoyl)-N-(2-nitrophenyl)benzamide	benzamides		low
3,4,5-trimethoxy-N-[4-[(2-methyl-1-piperidinyl)sulfonyl]phenyl]benzamide	benzamides		low
N-(4-methoxy-2-nitrophenyl)-3-[(2-methyl-1-oxopropyl)amino]benzamide	benzamides		low
3,4,5-triethoxy-N-[4-(4-methylsulfonyl-1-piperazinyl)phenyl]benzamide	benzamides		low
2-[[[4-[[2-(4-chloro-2-methylphenoxy)-1-oxopropyl]amino]phenyl]-oxomethyl]amino]benzoic acid	benzamides		low
N-(5-chloro-2-hydroxyphenyl)-2-ethoxybenzamide	benzamides		low
N-[2-[(2-furanylmethylamino)-oxomethyl]phenyl]-4-methyl-3-(1-piperidinylsulfonyl)benzamide	benzamides		low
4-methoxy-N-[4-[1-[(4-methoxyanilino)-oxomethyl]cyclopentyl]phenyl]benzamide	benzamides		low
N-[3-chloro-2-(1-piperidinyl)phenyl]-4-(4-morpholinyl)-3-nitrobenzamide	benzamides		low
N-[4-(6-imidazo[2,1-b]thiazolyl)phenyl]-4-methoxy-3-(4-morpholinylsulfonyl)benzamide	benzamides		low
norcisapride	benzamides		low
prucalopride	benzamides		low
Dihydroalatamide	benzamides		low
4-methoxy-N-[2,2,2-trichloro-1-(4-methylanilino)ethyl]benzamide	benzamides		low
N-(2-hydroxy-5-nitrophenyl)-3-nitrobenzamide	benzamides		low
N-[3-(1,3-benzothiazol-2-ylthio)-5-nitrophenyl]-2-fluorobenzamide	benzamides		low
N-[2-[5-[(4-tert-butylphenyl)methylthio]-1,3,4-oxadiazol-2-yl]phenyl]benzamide	benzamides		low
N-butan-2-yl-4-[4-oxo-3-(phenylmethyl)-2-thiazolidinyl]benzamide	benzamides		low
4-[3-(2-furanylmethyl)-4-oxo-2-thiazolidinyl]-N-(3-propan-2-yloxypropyl)benzamide	benzamides		low
2-methyl-N-[1-(4-prop-2-enyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)ethyl]benzamide	benzamides		low
N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(2-oxolanylmethyl)benzamide	benzamides		low
3-chloro-4-ethoxy-N-[3-(2-oxazolo[5,4-b]pyridinyl)phenyl]benzamide	benzamides		low
4-[[(3-methoxyphenyl)-oxomethyl]amino]benzoic acid	benzamides		low
3-[[oxo-[3-(1-piperidinylsulfonyl)phenyl]methyl]amino]benzoic acid	benzamides		low
N-(4-ethoxyphenyl)-2-(hydroxymethyl)benzamide	benzamides		low
N-(5-acetyl-2-phenyl-4-sulfanylidene-1H-pyrimidin-6-yl)benzamide	benzamides		low
sb-224289	1,2,4-oxadiazole; azaspiro compound; benzamides; organic heterotetracyclic compound	serotonergic antagonist	low
N-[(4-methylphenyl)methyl]-4-(1-pyrrolyl)benzamide	benzamides		low
1-[(4-chlorophenyl)-oxomethyl]-N-[4-(1-piperidinylsulfonyl)phenyl]-3-piperidinecarboxamide	benzamides; N-acylpiperidine		low
N-(4-bromophenyl)-2-[(5,6-dimethyl-4-thieno[2,3-d]pyrimidinyl)thio]benzamide	benzamides; thienopyrimidine		low
4-(3,5-dimethyl-1-pyrazolyl)-N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]benzamide	benzamides		low
N-[5-ethyl-3-[(4-fluorophenyl)-(4-morpholinyl)methyl]-2-thiophenyl]benzamide	benzamides		low
N-cycloheptyl-4-(2-oxolanylmethoxy)benzamide	benzamides		low
2-(4-methoxyphenyl)acetic acid [2-[4-[(4-ethoxyanilino)-oxomethyl]anilino]-2-oxoethyl] ester	benzamides		low
2-methyl-3-nitro-N-[4-[[(1-oxopropylamino)-sulfanylidenemethyl]amino]phenyl]benzamide	benzamides		low
N-[2-(3-methyl-1-oxobutyl)-3-oxo-1,2,4-thiadiazol-5-yl]benzamide	benzamides		low
2-[4-[[(3-chlorophenyl)-oxomethyl]amino]phenyl]propanedioic acid dimethyl ester	benzamides		low
N-(3,5-dimethylphenyl)-2-(2-nitroethyl)benzamide	benzamides		low
N-[4-[[(4-tert-butylphenyl)-oxomethyl]amino]phenyl]-2-furancarboxamide	benzamides		low
N-[3-[(4-ethoxyphenyl)-[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-4,5-dimethyl-2-thiophenyl]benzamide	benzamides		low
2-methoxy-N-(5-phenyl-1,2,4-thiadiazol-3-yl)benzamide	benzamides		low
N-(3-chlorophenyl)-4-fluoro-3-(thiophen-2-ylmethylsulfamoyl)benzamide	benzamides		low
3-acetamido-N-[(4-ethoxy-3-methoxyphenyl)methyl]-4-[(4-methylphenyl)thio]benzamide	benzamides		low
N-[3-(4-morpholinylsulfonyl)phenyl]-4-(2-oxo-1-pyrrolidinyl)benzamide	benzamides		low
N,N-dimethylsulfamic acid [3-[(4-methoxyanilino)-oxomethyl]phenyl] ester	benzamides		low
N-[1-(benzenesulfonyl)-2,2-dichloroethenyl]-4-methylbenzamide	benzamides		low
N-[4-chloro-3-[(4-chlorophenyl)sulfamoyl]phenyl]-4-propan-2-yloxybenzamide	benzamides		low
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	benzamides; benzodioxoles; imidazoles; pyridines	EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	low
N-[3-[(2-bromo-5-methylphenyl)sulfamoyl]-4-methoxyphenyl]-4-fluorobenzamide	benzamides		low
N-[2,5-diethoxy-4-(4-morpholinyl)phenyl]-4-[(3,5-dimethyl-4-isoxazolyl)methoxy]-3-methoxybenzamide	benzamides		low
4-methyl-N-[2-[(5-oxo-2,3-dihydrothiazolo[2,3-b]quinazolin-3-yl)methylthio]phenyl]benzamide	benzamides		low
4-cyano-N-[4-thiophen-2-yl-5-(2,2,2-trifluoro-1-oxoethyl)-2-thiazolyl]benzamide	benzamides		low
4-(1-azepanylsulfonyl)-N-[5-[(4-chlorophenyl)sulfamoyl]-2-hydroxyphenyl]benzamide	benzamides		low
N-[4-(4-fluorophenyl)-2-thiazolyl]-3-methoxy-4-[2-(4-morpholinyl)-2-oxoethoxy]benzamide	benzamides		low
N-[4-chloro-3-(4-morpholinylsulfonyl)phenyl]-4-(2-oxolanylmethoxy)benzamide	benzamides		low
N-[3-[(4-chlorophenyl)methylthio]-1H-1,2,4-triazol-5-yl]-4-cyanobenzamide	benzamides		low
2-(4-methylphenoxy)-N-[2-[oxo(1-piperidinyl)methyl]phenyl]acetamide	benzamides; N-acylpiperidine		low
imd 0354	benzamides		low
N-(3-chlorophenyl)-3-[ethyl(phenyl)sulfamoyl]-4-fluorobenzamide	benzamides		low
4-tert-butyl-N-[3-[4-[3-[[(4-tert-butylphenyl)-oxomethyl]amino]propyl]-1-piperazinyl]propyl]benzamide	benzamides		low
2-nitro-4-[(6-nitro-4-quinolinyl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide	benzamides		low
4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide	benzamides		low
tiapridex	benzamides		low
[2-methoxy-5-[[4-(4-methylphenyl)-1-phthalazinyl]amino]phenyl]-(1-piperidinyl)methanone	benzamides; N-acylpiperidine		low
axitinib	aryl sulfide; benzamides; indazoles; pyridines	antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist	low
4-[(2,4-dioxo-1H-thieno[3,2-d]pyrimidin-3-yl)methyl]-N-(3-ethylphenyl)benzamide	benzamides		low
LSM-32377	benzamides		low
ispinesib	benzamides		low
fk 866	benzamides; N-acylpiperidine		low
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamide	benzamides		low
[4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone	benzamides; N-acylpiperidine		low
midostaurin	benzamides; gamma-lactam; indolocarbazole; organic heterooctacyclic compound	antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor	low
bms201038	(trifluoromethyl)benzenes; benzamides; fluorenes; piperidines	anticholesteremic drug; MTP inhibitor	low
mocetinostat	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent	low
cgp 74588	benzamides		low
zm 447439	aromatic ether; benzamides; morpholines; polyether; quinazolines; secondary amino compound; tertiary amino compound	antineoplastic agent; apoptosis inducer; Aurora kinase inhibitor	low
tak-715	benzamides		low
masitinib	1,3-thiazoles; benzamides; N-alkylpiperazine; pyridines	antineoplastic agent; antirheumatic drug; tyrosine kinase inhibitor	low
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide	1,3,4-oxadiazoles; benzamides; biphenyls; nitrile	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	low
betrixaban	benzamides; guanidines; monochloropyridine; monomethoxybenzene; secondary carboxamide	anticoagulant; EC 3.4.21.6 (coagulation factor Xa) inhibitor	low
nigerloxin	aromatic ether; benzamides; benzoic acids; phenols; styrenes	antioxidant; Aspergillus metabolite; EC 1.1.1.21 (aldehyde reductase) inhibitor; lipoxygenase inhibitor; radical scavenger	low
myxochelin b	benzamides; catechols	bacterial metabolite; siderophore	low
fluopicolide	benzamide fungicide; benzamides; dichlorobenzene; monochloropyridine; organofluorine compound	antifungal agrochemical	low
eluxadoline	amino acid amide; benzamides; imidazoles; L-phenylalanine derivative; methoxybenzoic acid	delta-opioid receptor antagonist; gastrointestinal drug; kappa-opioid receptor agonist; mu-opioid receptor agonist	low
N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide	benzamides		low
N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide	benzamides		low
chir 090	acetylenic compound; benzamides; hydroxamic acid; L-threonine derivative; morpholines	antimicrobial agent; EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor; lipopolysaccharide biosynthesis inhibitor	low
ki11502	aromatic ether; benzamides; quinolines; thioureas	antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	low
az-628	benzamides		low
at 13387	benzamides; isoindoles; N-alkylpiperazine; resorcinols; tertiary carboxamide	antineoplastic agent; Hsp90 inhibitor	low
4-[[[2-(cyclohexylamino)-3,4-dioxo-1-cyclobutenyl]amino]methyl]-N-(4-ethoxyphenyl)benzamide	benzamides		low
chidamide	benzamides		low
N-(3,5-dichlorophenyl)-4-[(2,4-dioxo-1H-thieno[3,2-d]pyrimidin-3-yl)methyl]benzamide	benzamides		low
mdv 3100	(trifluoromethyl)benzenes; benzamides; imidazolidinone; monofluorobenzenes; nitrile; thiocarbonyl compound	androgen antagonist; antineoplastic agent	low
3-nitro-4-(2-oxolanylmethylamino)-N-(2-phenylethyl)benzamide	benzamides		low
2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino)benzamide	aminopyrimidine; benzamides	protein kinase inhibitor	low
azd 7545	benzamides; monochlorobenzenes; organofluorine compound; secondary carboxamide; sulfone; tertiary alcohol; tertiary carboxamide	EC 2.7.11.2 - [pyruvate dehydrogenase (acetyl-transferring)] kinase inhibitor; hypoglycemic agent	low
N-[3-[2-(4-chloroanilino)-4-thiazolyl]phenyl]-3-(trifluoromethyl)benzamide	benzamides		low
3-(trifluoromethyl)-N-[4-[2-[3-(trifluoromethyl)anilino]-4-thiazolyl]phenyl]benzamide	benzamides		low
2-amino-N-[3-methoxy-5-[oxo-[3-(trifluoromethyl)anilino]methyl]phenyl]-5-oxazolecarboxamide	benzamides		low
2-amino-N-[3-methoxy-5-[oxo-[3-(trifluoromethyl)anilino]methyl]phenyl]-4-thiazolecarboxamide	benzamides		low
2-amino-N-[3-methoxy-5-[oxo-[3-(trifluoromethyl)anilino]methyl]phenyl]-4-pyridinecarboxamide	benzamides		low
3-(4-bromophenyl)-N-[5-[[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)anilino]-oxomethyl]-2-methylphenyl]-1H-pyrazole-5-carboxamide	benzamides		low
N-[3-amino-1-[4-[2-(4-methoxyphenyl)ethylamino]-3-nitrophenyl]-3-oxopropyl]-4-bromobenzamide	benzamides		low
nvp-bhg712	benzamides		low
respirantin	benzamides; cyclodepsipeptide; formamides; phenols	antimicrobial agent; antineoplastic agent; metabolite	low
N-[5-[[5-[(4-acetyl-1-piperazinyl)-oxomethyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[(3-methylbutan-2-ylamino)methyl]benzamide	benzamides		low
ph 797804	aromatic ether; benzamides; organobromine compound; organofluorine compound; pyridone	anti-inflammatory agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	low
2-[[4-(2-hydroxyethylamino)-6-(1-pyrrolidinyl)-1,3,5-triazin-2-yl]amino]benzamide	benzamides		low
lde225	aminopyridine; aromatic ether; benzamides; biphenyls; morpholines; organofluorine compound; tertiary amino compound	antineoplastic agent; Hedgehog signaling pathway inhibitor; SMO receptor antagonist	low
gdc 0449	benzamides; monochlorobenzenes; pyridines; sulfone	antineoplastic agent; Hedgehog signaling pathway inhibitor; SMO receptor antagonist; teratogenic agent	low
3-[[1-[1-(methylthio)propan-2-yl]-4-piperidinyl]oxy]-N-(2-pyridinylmethyl)benzamide	benzamides		low
3-[[1-(dimethylsulfamoyl)-4-piperidinyl]oxy]-N-[(3-methyl-5-isoxazolyl)methyl]benzamide	benzamides		low
ponatinib	(trifluoromethyl)benzenes; acetylenic compound; benzamides; imidazopyridazine; N-methylpiperazine	antineoplastic agent; tyrosine kinase inhibitor	low
N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide	benzamides; biphenyls; cyclopropanes; dicarboxylic acid diamide	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	low
4-tert-butyl-N-[5-[[2-oxo-2-(2-oxolanylmethylamino)ethyl]thio]-1,3,4-thiadiazol-2-yl]benzamide	benzamides		low
4-ethoxy-N-[5-[[2-oxo-2-(2-oxolanylmethylamino)ethyl]thio]-1,3,4-thiadiazol-2-yl]benzamide	benzamides		low
GRL-0617	benzamides; naphthalenes; secondary carboxamide; substituted aniline	anticoronaviral agent; protease inhibitor	low
n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide	aminopyrimidine; benzamides; morpholines; nitrile; secondary amino compound; tertiary amino compound	anti-anaemic agent; antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	low
N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide	benzamides		low
entrectinib	benzamides; difluorobenzene; indazoles; N-methylpiperazine; oxanes; secondary amino compound; secondary carboxamide	antibacterial agent; antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	low
ixazomib	benzamides; boronic acids; dichlorobenzene; glycine derivative	antineoplastic agent; apoptosis inducer; drug metabolite; orphan drug; proteasome inhibitor	low
N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]anilino]-5-fluoro-4-pyrimidinyl]amino]benzamide	benzamides		low
N-[(2S,3S)-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-2-(methylaminomethyl)-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-(2-thiazolyl)benzamide	benzamides		low
N-(2-aminophenyl)-4-[[[(2S,3S)-10-[[cyclohexyl(oxo)methyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl-methylamino]methyl]benzamide	benzamides		low
KOM70144	acetamides; benzamides; naphthalenes; secondary carboxamide	anticoronaviral agent; protease inhibitor	low
iwr-1 endo	benzamides; bridged compound; dicarboximide; quinolines	axin stabilizer; Wnt signalling inhibitor	low
ulixacaltamide	benzamides; monochlorobenzenes; monofluorobenzenes; piperidines; secondary carboxamide	non-narcotic analgesic; T-type calcium channel blocker	low
xl765	aromatic amine; aromatic ether; benzamides; quinoxaline derivative; sulfonamide	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor	low
azd4547	benzamides; N-arylpiperazine; pyrazoles	fibroblast growth factor receptor antagonist	low
N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide	benzamides; N-acylpiperidine		low
entecavir	benzamides; N-acylpiperidine		low
acp-196	aromatic amine; benzamides; imidazopyrazine; pyridines; pyrrolidinecarboxamide; secondary carboxamide; tertiary carboxamide; ynone	antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	low
pf-06463922	aminopyridine; aromatic ether; azamacrocycle; benzamides; cyclic ether; monofluorobenzenes; nitrile; organic heterotetracyclic compound; pyrazoles	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	low
DDR1-IN-1	(trifluoromethyl)benzenes; aromatic ether; benzamides; N-alkylpiperazine; oxindoles; secondary carboxamide	EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	low
N-[2-methyl-5-[oxo-[3-(1-oxoprop-2-enylamino)-5-(trifluoromethyl)anilino]methyl]phenyl]-5-isoxazolecarboxamide	benzamides		low
PF-06446846	benzamides; monochloropyridine; piperidines; tertiary carboxamide; triazolopyridine	antilipemic drug; EC 3.4.21.61 (kexin) inhibitor	low
5,10-methylenetetrahydrofolic acid	benzamides; methylenetetrahydrofolic acid		low
N-cyclohexyl-3-methyl-N-[(4-oxo-1H-quinazolin-2-yl)methyl]benzamide	benzamides		low

Condition	Indicated	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
Inflammation	0	1	2010	2010	14.0	high	0	0	0	1	0	0
Innate Inflammatory Response	0	1	2010	2010	14.0	high	0	0	0	1	0	0